La Liga September 12 Preview: Sevilla vs Valencia & Osasuna vs Espanyol | Predictions and Score Tips

La Liga Matchday 5 continues on September 12 with two interesting fixtures for Indian football fans. Sevilla host struggling Valencia at the Ramon Sanchez-Pizjuan, while Osasuna take on Espanyol at El Sadar.

Sevilla vs Valencia is the bigger fixture of the two, with Los Che under serious pressure after a disastrous start to the 2026/27 campaign.

Sevilla vs Valencia

Kick-off: September 12, 12:30 AM IST

Sevilla have made a solid start to the new La Liga season, collecting seven points from four matches with two wins, one draw and one defeat.

They opened the campaign with back-to-back victories before losing 3-1 to Atletico Madrid. Sevilla then responded with a 1-1 draw away at Espanyol despite playing with 10 men for a significant period of the second half.

Valencia, meanwhile, are going through a very difficult period.

Los Che sit bottom of La Liga with just one point from four matches. They have scored only once while conceding nine goals, and are still searching for their first league victory of the season.

Their injury situation makes this trip even more difficult. Umar Sadiq, Diego Lopez, Jose Manuel Copete and Dimitri Foulquier are among the players currently sidelined, while Mouctar Diakhaby, Guido Rodriguez, Justin de Haas and Luis Rioja are also major fitness concerns.

Sevilla also have some selection issues, with Arouna Sangante suspended and Ruben Vargas a fitness doubt, but their situation is considerably better than Valencia's.

With home advantage and better early-season form, Sevilla should enter this contest as favourites.

Match Prediction: Sevilla to win
Goals Outlook: 2–3 goals
Score Tips: 2-0 or 2-1

Final Score Prediction: Sevilla 2-0 Valencia

Valencia's injury-hit defence and poor attacking form make Sevilla the stronger pick. Unless Los Che improve significantly, the hosts should have enough quality to take all three points.

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Osasuna vs Espanyol

Kick-off: September 12, 7:45 PM IST

Osasuna return to El Sadar looking to bounce back from a heavy defeat against Alaves.

The hosts had made an impressive start to the campaign with two wins and one draw from their opening three matches, but their unbeaten run ended with a surprising 5-2 defeat away to Alaves.

Despite that setback, Osasuna still have seven points from four matches and remain above Espanyol in the table.

Espanyol have collected four points from their opening four games, scoring six and conceding five. Their latest match ended in a 1-1 draw against Sevilla.

Injuries could have a major influence on this fixture.

Osasuna are expected to be without Jorge Herrando, Aimar Oroz and Moi Gomez, while Valentin Rosier is also a doubt. Moi Gomez has been ruled out after suffering a hamstring injury.

Espanyol also have attacking concerns, with Javi Puado and Kike Garcia currently sidelined.

Home advantage gives Osasuna a slight edge, but their defensive collapse against Alaves means Espanyol cannot be written off.

Statistical models also lean towards the hosts, with recent projections putting an Osasuna victory at around 44–46%, while a low-scoring contest is considered likely.

Match Prediction: Osasuna to win or draw
Goals Outlook: Under 2.5 goals
Score Tips: 1-0 or 1-1

Final Score Prediction: Osasuna 1-0 Espanyol

Osasuna's home advantage could make the difference at El Sadar. Espanyol should keep the game competitive, but their away form and attacking absences make a narrow home victory the more attractive prediction.

Overall picks: Sevilla to beat Valencia is the stronger selection of the two, while Osasuna vs Espanyol looks much tighter and more likely to produce a low-scoring result. For your India/Medium SEO, I would keep “Sevilla vs Valencia” first in the title because it is the more attractive fixture for this date.